Effects of Platelet-Rich Plasma on Proliferation and Myofibroblastic Differentiation in Human Dermal Fibroblasts
作者： Satoshi Kushida , Natsuko Kakudo , Kenji Suzuki , Kenji Kusumoto
DOI: 10.1097/SAP.0B013E31823CD7A4
关键词:
摘要: Platelet-rich plasma (PRP) is that produced from autologous blood, and its usefulness in plastic surgery dermal wound healing has garnered attention recent years. The aim of this study was to investigate the effects PRP platelet-poor on proliferation differentiation skin fibroblasts into myofibroblasts contraction using Western blotting, immunofluorescence staining, collagen gels containing an embedded fibroblast model. promotes human fibroblasts. addition enhanced expression alpha-smooth muscle actin protein, a myofibroblast marker, as shown by staining blotting. PRP-treated groups demonstrated more marked gel model than vehicle groups. proliferation, causes contraction, thus providing potential therapeutic agent for healing.
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