作者: Yiwei Lin , Yadi Wu , Junlin Li , Chenfang Dong , Xiaofeng Ye
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摘要: Epithelial–mesenchymal transition (EMT) is a transdifferentiation programme. The mechanism underlying the epigenetic regulation of EMT remains unclear. In this study, we identified that Snail1 interacted with histone lysine-specific demethylase 1 (LSD1). We demonstrated SNAG domain and amine oxidase LSD1 were required for their mutual interaction. Interestingly, sequence similar to H3 tail, interaction can be blocked by enzymatic inhibitors peptide. found formation Snail1–LSD1–CoREST ternary complex was critical stability function these proteins. co-expression molecules in cancer cell lines breast tumour specimens. Furthermore, showed recruiting its target gene promoters resulted suppression migration invasion. Our study suggests resembles H3-like structure functions as molecular hook repress expression metastasis.