Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 25(OH)D concentrations in healthy women

摘要: Circulating 25 hydroxyvitamin D (25 (OH)D), an accurate measure of vitamin status, is markedly greater in individuals with increased exposure to ultraviolet B (UVB) light via sunlight or the use artificial UV light. Aside from known relationship between and bone, has also been implicated immune function inflammation. Furthermore, a mass evidence accumulating that deficiency could lead malfunction. Our overall objective was study status (as determined by serum 25(OH) concentrations) inflammatory markers healthy women. This observational included 69 women, age 25–82 years. Women high UVB women minimal were specifically recruited obtain wide-range 25(OH)D concentrations. Health, sun habitual dietary intake information obtained all subjects. Body composition dual-energy-x-ray absorptiometry. A fasting blood sample collected morning analyzed for 25(OH)D, parathyroid hormone (iPTH), estradiol (E2), cortisol, [tumor necrosis factor -alpha (TNF-α), interleukin-6 -10 (IL-6, IL-10), C-reactive protein (CRP)]. regular (Hi-D) had concentrations significantly higher (p < 0.0001) iPTH lower than without (Lo-D). Although IL-6, IL-10, CRP did not have statistically significant concentrations, linear regression models revealed inverse TNF-α remained after controlling potential covariates such as body fat mass, menopausal age, hormonal contraceptive use. Serum inversely related which may part explain this vitamin's role prevention treatment diseases. Results gleaned investigation support need re-examine biological basis determining optimal status.