The expression of angiopoietin-1 and -2 in the endometrium of women with abnormal bleeding induced by an intra-uterine device.
作者： HL Qian , HF Wang , ML Yang
DOI: 10.1177/147323001003800112
关键词:
摘要: This study identified differences in expression of angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) the endometrium 33 women with abnormal bleeding induced by an intra-uterine device (IUD; 23 proliferative phase, 10 secretory phase) compared 28 control samples from normal endometria without IUD fitted (12 16 phase). Expression Ang-1, Ang-2 endothelial cell-specific tyrosine kinase receptor-2 (Tie-2) mRNA was detected reverse transcription-polymerase chain reaction (RT-PCR), Ang-1 protein levels were immunohistochemistry. The RT-PCR results showed significantly decreased patients during both phases women. Tie-2 Ang-1:Ang-2 ratio also phase Immunohistochemical analysis elevated These suggest that angiopoietin/Tie-2 system promotes vascular remodelling changes may contribute to uterine some users.
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