Signal cross talks for sustained MAPK activation and cell migration: the potential role of reactive oxygen species

摘要: Signal transduction exerted by the microenvironment around primary tumor locus may trigger metastasis especially at migration stage. Sustained mitogen activated protein kinase (MAPK) signaling involved in uncontrolled cell rely on cross talks between integrin, receptor tyrosine (RTK) and C (PKC). The molecular mechanisms for talking these migration-related signal cascades leading to sustained are reviewed, focusing focal adhesion scaffold paxillin as platform integration. We proposed reactive oxygen species (ROS) critical messenger sustaining cascades. For talk of integrin with RTK, ROS suppress paxillin-associated phosphatase (PTP-PEST) relieving its negative regulatory effects. PKC, PKC itself phosphorylate or proteins induce generation which reactivate PKC. In future, will be validated promising therapeutic targets prevention metastasis.