Modulation of metabolic control by angiotensin converting enzyme (ACE) inhibition.

摘要: Angiotensin converting enzyme (ACE) inhibitors are a widely used intervention for blood pressure control, and particularly beneficial in hypertensive type 2 diabetic subjects with insulin resistance. The hemodynamic effects of ACE associated enhanced levels the vasodilator bradykinin decreased production vasoconstrictor growth factor angiotensin II (ATII). In insulin-resistant conditions, can also enhance whole-body glucose disposal transport activity skeletal muscle. This review will focus on metabolic consequences inhibition At cellular level, acutely uptake muscle via two mechanisms. One mechanism involves action bradykinin, acting through B2 receptors, to increase nitric oxide (NO) ultimately transport. A second diminution inhibitory ATII, AT1 system. acute actions upregulation signaling, including IRS-1 tyrosine phosphorylation phosphatidylinositol-3-kinase activity, increased cell-surface GLUT-4 transporter protein. Chronic administration or antagonists rodents protein expression myocardium. These data support concept that beneficially modulate control states, possibly NO-dependent effect and/or antagonism ATII © 2003 Wiley-Liss, Inc.