Single nucleotide polymorphisms in colorectal cancer: associations with tumor site and TNM stage.
作者： Mates In , Mates D , Constantin A , Jinga , Csiki Ie
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摘要: BACKGROUND AND AIM Colon tumor carcinogenesis and rectal have each been associated with different genetic features, but data are still controversial insufficient to support their distinct molecular biology. Recently, genome-wide association studies (GWAS) also found heterogeneity in colorectal cancer (CRC) risks based on population ethnicity features. Several single nucleotide polymorphism (SNP) markers described the literature as having site and/or stage specificity, including rs10795668, rs3802842, rs6983267, rs4939827. Replication of initial findings ethnic groups by independent is required unravel population-specific differences risk. METHODS We examined whether inherited risk variants at rs4939827 exerted a differential effect colon cancers Romanian hospital series 153 CRC cases 182 non-affected control subjects prospectively recruited between 2007 2010. RESULTS Rectal tumors were significantly (OR = 4.85, P 0.002) rs6983267 3.00, 0.036), suggesting that carriers alleles these loci had increased susceptibility development rather than cancer. Carrying C allele rs3802842 appeared be lower for our dataset. no genotypes aggressiveness reflected TNM staging. CONCLUSIONS The associations SNPs, staging remain further clarified. Our results should considered cautiously, may taken into account future, larger epidemiological studies.
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