A DNA-inspired synthetic ion channel based on G-C base pairing.

摘要: A dinucleoside containing guanosine and cytidine at the end groups has been prepared using a modular one-pot azide–alkyne cycloaddition. Single channel analysis showed that this predominantly forms large channels with 2.9 nS conductance for transport of potassium ions across phospholipid bilayer. Transmission electron microscopy, atomic force circular dichroism spectroscopy studies reveal can spontaneously associate through Watson–Crick canonical H-bonding π–π stacking to form stable supramolecular nanostructures. Most importantly, ion activity G–C be inhibited nucleobase cytosine.