Steroidogenic differential effects in neonatal porcine Leydig cells exposed to persistent organic pollutants derived from cod liver oil.
作者： Cesilie Granum , Sara Anchersen , Camilla Karlsson , Vidar Berg , Ingrid Olsaker
DOI: 10.1016/J.REPROTOX.2015.05.016
关键词:
摘要: Seafood products, including fish and oils, are major sources of persistent organic pollutants (POPs) which may cause endocrine disruption related to reproductive dysfunction in males. Primary porcine neonatal Leydig cells were exposed three extracts POPs obtained from different stages production cod liver oil dietary supplement, the absence presence luteinizing hormone (LH). No reduced viability was observed all POP showed increased testosterone estradiol levels unstimulated decreased secretion LH-stimulated cells. A decrease central steriodogenic genes STAR, CYP11A1, HSD3B CYP17A1 both culture conditions with extracts. We implicate small differences composition concentration compounds as well "old" be important for steroidogenic effects.
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