摘要: We have analyzed the patterns of positive and negative selection thymocytes expressing T cell antigen receptor (TCR) from D10.G4.1 clone. This TCR confers reactivity to several non-self MHC class II alleles with a remarkably broad range avidities. Therefore, can be studied when induced by high-, intermediate-, or low-avidity interactions endogenous peptide–MHC complexes, all within same transgenic system. These data directly demonstrate that II–peptide ligands fail activate mature cells promote immature thymocytes. Additionally, we show occur at two distinct “time points” during development depending on avidity for MHC–peptide complex. Finally, self-peptide repertoire plays significant role in because alteration disruption H2-Ma gene drastically alters D10 TCR-expressing
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