Peroxiredoxin6, a Multitask Antioxidant Enzyme Involved in the Pathophysiology of Chronic Noncommunicable Diseases.
作者： Francesca Pacifici , David Della Morte , Barbara Capuani , Donatella Pastore , Alfonso Bellia
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摘要: Abstract Significance: Chronic noncommunicable diseases (NCDs) are the leading causes of disability and death worldwide. NCDs mainly comprise diabetes mellitus, cardiovascular diseases, chronic obstructive pulmonary disease, cancer, neurological degenerative which kill more than 80% population, especially elderly, Recent Advances: Several recent theories established as multifactorial where a combination genetic, epigenetic, environmental factors contributes to their pathogenesis. Nevertheless, findings suggest that common factor linking all these pathologies is an increase in oxidative stress age-related loss antioxidant mechanisms defense against it. Impairment mitochondrial homeostasis with consequent deregulation balance has also been suggested. Critical Issues: Therefore, proteins deserve particular attention for potential role NCDs. In particular, peroxiredoxin(Prdx)6 is...
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