Population-Based Study of Risk of AKI with Levetiracetam.
作者： Kevin Yau , Jorge G. Burneo , Racquel Jandoc , Eric McArthur , Flory Tsobo Muanda
DOI: 10.2215/CJN.07490618
关键词:
摘要: Background and objectives Regulatory agencies warn about the risk of AKI with levetiracetam use on basis information from case reports. We conducted this study to determine whether new versus nonuse is associated a higher AKI. Design, setting, participants, & measurements This was population-based retrospective cohort adults epilepsy in Ontario, Canada. Patients who received outpatient prescription for between January 1, 2004 March 2017 were matched two nonusers stage CKD, recorded seizure prior 90 days, logit propensity score use. The primary outcome hospital encounter (emergency department visit or hospitalization) within 30 days entry. Secondary outcomes 180 change concentration serum creatinine. assessed using health care diagnosis codes. evaluated creatinine subpopulation laboratory measurements. Results 3980 users 7960 (mean age 55 years, 51% women). Levetiracetam not significantly (13 [0.33%] events 21 [0.26%] [odds ratio, 1.24; 95% confidence interval, 0.62 2.47]). Similarly, there no significant association (odds 0.70; 0.43 1.13). did differ nonusers. Conclusions In Podcast article contains podcast at https://www.asn-online.org/media/podcast/CJASN/2018_12_11_Yau_Podcast.mp3
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elsevier.com参考文章(44)
Paul Grootendorst, Bernie J O'Brien, Adrian R Levy, Donald Willison, Connie Sellors, Coding accuracy of administrative drug claims in the Ontario Drug Benefit database. The Canadian journal of clinical pharmacology. ,vol. 10, pp. 67- 71 ,(2003)
P.N. Patsalos, Pharmacokinetic profile of levetiracetam: toward ideal characteristics. Pharmacology & Therapeutics. ,vol. 85, pp. 77- 85 ,(2000) , 10.1016/S0163-7258(99)00052-2
Faruk Incecik, Ozlem M. Herguner, Seyda Besen, Sakir Altunbasak, Acute rhabdomyolysis associated with levetiracetam therapy in a child. Acta Neurologica Belgica. ,vol. 116, pp. 369- 370 ,(2016) , 10.1007/S13760-015-0542-9
Mathieu Leblanc, Martin Plaisance, Levetiracetam-Associated Acute Kidney Injury and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome Open Journal of Nephrology. ,vol. 04, pp. 152- 155 ,(2014) , 10.4236/OJNEPH.2014.44022
Daniel S. Streetman, Stephen M. Stout, Is there a clinically relevant interaction between clarithromycin and statins not metabolized by cytochrome P450 3A4 Canadian Medical Association Journal. ,vol. 187, pp. 163- 165 ,(2015) , 10.1503/CMAJ.150030
Andrew W.Y. Shih, Matthew A. Weir, Kristin K. Clemens, Zhan Yao, Tara Gomes, Muhammad M. Mamdani, David N. Juurlink, Amanda Hird, Anthony Hodsman, Chirag R. Parikh, Ron Wald, Suzanne M. Cadarette, Amit X. Garg, Oral bisphosphonate use in the elderly is not associated with acute kidney injury Kidney International. ,vol. 82, pp. 903- 908 ,(2012) , 10.1038/KI.2012.227
Hisanao Akiyama, Yoshiteru Haga, Naoshi Sasaki, Toshiyuki Yanagisawa, Yasuhiro Hasegawa, A case of rhabdomyolysis in which levetiracetam was suspected as the cause Epilepsy and behavior case reports. ,vol. 2, pp. 152- 155 ,(2014) , 10.1016/J.EBCR.2014.08.001
Danielle C. Spengler, Georgia D. Montouris, Anna D. Hohler, Levetiracetam as a Possible Contributor to Acute Kidney Injury Clinical Therapeutics. ,vol. 36, pp. 1303- 1306 ,(2014) , 10.1016/J.CLINTHERA.2014.06.002
M.J Morrell, I Leppik, J French, J Ferrendelli, J Han, L Magnus, The KEEPER trial: levetiracetam adjunctive treatment of partial-onset seizures in an open-label community-based study. Epilepsy Research. ,vol. 54, pp. 153- 161 ,(2003) , 10.1016/S0920-1211(03)00080-9
Ngan N. Lam, Matthew A. Weir, Zhan Yao, Peter G. Blake, Michael M. Beyea, Tara Gomes, Sonja Gandhi, Muhammad Mamdani, Ron Wald, Chirag R. Parikh, Daniel G. Hackam, Amit X. Garg, Risk of Acute Kidney Injury From Oral Acyclovir: A Population-Based Study American Journal of Kidney Diseases. ,vol. 61, pp. 723- 729 ,(2013) , 10.1053/J.AJKD.2012.12.008