Cocaine-induced conditioned taste aversions: comparisons between effects in LEW/N and F344/N rat strains

摘要: Recent studies have found the LEW/N rat self-administers drugs of abuse at higher rates than F344/N rat, suggesting a genetic predisposition toward potential drugs. The current study compared acquisition conditioned taste aversion (CTA) to cocaine in these strains. During an initial 20-min daily session 0.1% saccharin solution was available and dose (0–50 mg/kg, SC) given immediately after that session. Water during sessions on following 3 days. Fluid consumption assessed over three saccharin/water cycles, final Vehicle injections (0 mg/kg) followed exposure had no effect subsequent consumption. In contrast, when saccharin, decreased successive dose-related manner both lowest (18 rats but not rats. An intermediate (32 maximally only marginally highest (50 completely almost These findings demonstrate significant differences sensitivity stimuli paired with occur between are consistent previous reports is uniquely sensitive behavioral biochemical effects abuse. report extends this noxious To extent reinforcing unrelated, results suggest does exhibit factors related