Allogeneic bone marrow transplantation for refractory and recurrent low-grade lymphoma: the case for aggressive management.
作者： K W van Besien , I F Khouri , S A Giralt , P McCarthy , R Mehra
DOI: 10.1200/JCO.1995.13.5.1096
关键词:
摘要: PURPOSETo evaluate the role of allogeneic bone marrow transplantation (BMT) in recurrent low-grade lymphoma.PATIENTS AND METHODSBetween 1989 and 1994, 10 patients with chemotherapy-refractory lymphoma were treated myeloablative therapy BMT. All had poor prognostic features been extensively pretreated.RESULTSEight achieved a complete remission none have relapsed at median follow-up time 816 days (range, 346 to 1,865). Two died early complications. The actuarial survival failure-free rates are both 80% +/- 12.6%. For surviving patients, duration current exceeds that any previous achieved.CONCLUSIONThese results compare favorably those for autologous Allogeneic BMT offers considerable promise treatment poor-prognosis lymphoma. Its should be further defined prospective studies.
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