Application of combinatorial chemistry science on modern drug discovery.
作者： J. Phillip Kennedy , Lyndsey Williams , Thomas M. Bridges , R. Nathan Daniels , David Weaver
DOI: 10.1021/CC700187T
关键词:
摘要: The science that established combinatorial chemistry as important new discipline in the 1980s and 1990s has re-emerged infiltrated every sub-discipline within modern drug discovery profound impact. application of revolutioned high-throughput screening paradigms, chemical lead optimization, library purification, post-purification sample handling, well vitro vivo metabolism pharmacokinetic assays. Although no longer spotlight heralded savior industry, “combinatorial chemistry” is alive well; fact, more prevalent wide-spread than ever before.
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