Drugs inducing or aggravating parkinsonism: a review.

摘要: Drug-induced parkinsonism (DIP) is frequent. The list of drugs able to induce long and probably incomplete, because new drugs, with previously unknown antidopaminergic activity, are constantly being added. Not all the have same potency for inducing parkinsonism. We classify these in three groups: (1) obvious activity which regularly parkinsonism; (2) particular individuals (3) may aggravate Parkinson's disease treated levodopa. reports isolated cases induced by widely-used (drugs group 2) be result either an idiosyncratic side effect or a misdiagnosis this weak not sufficiently demonstrated. Maybe, cases, blockage other neurotransmitters different from dopamine plays role induction Probably, number patients DIP higher than reported detected, many suffer symptoms that quickly disappear after drug withdrawal. One main points interest knowing list, specially those 1, should avoided used caution treatment some common symptomatic problems disease, such as depression, arterial hypertension, diabetes mellitus cardiac disorders. precautions extent populations especially susceptible DIP, elderly neurodegenerative disorders, Alzheimer's disease.