Cerebral ischemia: gene activation, neuronal injury, and the protective role of antioxidants
作者： James A Clemens
DOI: 10.1016/S0891-5849(00)00258-6
关键词:
摘要: A large number of gene products appear after an ischemic insult making it difficult to decipher which genes are involved in tissue injury. Reactive oxygen species (ROS) can influence expression and have a role the events that lead neuronal death. In global cerebral ischemia oxidative responsive transcription factor, NF-kappa B, is persistently activated neurons destined die. There several potential routes through B act induce death, including production death proteins aborted attempt reenter cell cycle. only transiently survive. Persistent activation be blocked by antioxidants, suggests neuroprotective effect antioxidants may due inhibiting B.
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