Essential role of NMDA receptor channel ε4 subunit (GluN2D) in the effects of phencyclidine, but not methamphetamine.
作者： Yoko Hagino , Shinya Kasai , Wenhua Han , Hideko Yamamoto , Toshitaka Nabeshima
DOI: 10.1371/JOURNAL.PONE.0013722
关键词:
摘要: Phencyclidine (PCP), a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, increases locomotor activity in rodents and causes schizophrenia-like symptoms humans. Although activation of the dopamine (DA) pathway is hypothesized to mediate these effects PCP, precise mechanisms by which PCP induces its remain be elucidated. The present study investigated effect on extracellular levels DA (DAex) striatum prefrontal cortex (PFC) using vivo microdialysis mice lacking NMDA channel e1 or e4 subunit (GluRe1 [GluN2A] GluRe4 [GluN2D]) activity. significantly increased DAex wildtype GluRe1 knockout mice, but not PFC. Acute repeated administration did increase mice. results suggest that enhances dopaminergic transmission acting at GluRe4.
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