Highly Functionalized Modified Metal Oxides Polymeric Sensors for Potentiometric Determination of Letrozole in Commercial Oral Tablets and Biosamples.
作者： Maha Farouk El-Tohamy , Ahmed Mahmoud Shawky
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摘要: The advanced and high-functional activities of magnesium oxide copper nanoparticles encourage the extensive use these metal oxides as remarkable electroactive materials in electrochemical sensing detections. current study described a comparative activity selectivity modified coated wire membrane sensors enriched with for quantifying breast cancer medication letrozole (LTZ) its pharmaceutical form human plasma. fabricated were based on incorporation LTZ phosphomolybdic acid (PMA) to complex letrozole-phosphomolybate (LTZ-PM) presence o-nitrophenyloctyl ether (o-NPOE) solvent mediator. Under optimum conditions, LTZ-PM-MgONPs LTZ-PM-CuONPs demonstrated linear relationships 1.0 × 10-8-1.0 10-2 10-10-1.0 mol L-1, respectively. Least square equations calculated EmV = (56.4 ± 0.7) log [LTZ] + 569.6 (58.7 0.3) 692.6 LTZ-PM-CuONPs, conventional type LTZ-PM showed potential response (53.3 0.5) 451.4 over concentration range 10-6-1.0 L-1. suggested successfully used determine formulations biosamples. Method validation ensured suitability potentiometric sensors.
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