Cervical preparation using laminaria with adjunctive buccal misoprostol before second-trimester dilation and evacuation procedures: A randomized clinical trial

摘要: Objective This study was undertaken to determine whether buccal misoprostol improves cervical preparation achieved with laminaria before second-trimester dilation and evacuation procedures. Study design A randomized, double blind, placebo-controlled trial of preoperative overnight either placebo or 400 μg approximately 90 minutes surgical abortion. Block randomization used provide balanced enrollment into 2 separate gestational age groups: early (13-15 6/7 ) mid (16-20 second trimester. Surgeons tested maximal by inserting the largest dilator that could be passed through os without force. Subject demographics preprocedure symptoms were tracked. Results Groups similar in regard age, gravity, parity, delivery type, age. Data analyzed from 125 women 13 15 (30 misoprostol, 32 placebo) 16 20 (31 groups. Overall, treatment did not improve initial mean alone (46.0 ƒr ± 5.0; 45.0 6.2, P = .68) (50.9 5.6, 48.9 5.2, .16) However, a subanalysis gestations 19 weeks more demonstrated significantly greater group (53.6 5.3, 48.5 5.0, .01). Subjects receiving reported cramping than those 25/30, 83%; 17/32, 53%, .02; 16-20 week 25/31, 81%, 16/32, 50%, .02). Conclusion Cervical is augmented more, but earlier gestations. Misoprostol causes abdominal cramping.