Nonlinear elastic brain tissue model for neural probe-tissue mechanical interaction

摘要: The reliability of long-term recording implantable neural probes depends on several factors, including adverse tissue response which forms astroglial sheath scarring around the probe. Brain micromotion is one possible causes this reaction. It creates localized strain probe tip, leading to shear-induced inflammation at implant site. Although induced by brain may exceed accepted linear range for biological tissues, models have been employed in most modeling studies. Hence, aim investigation verify validity assuming small-strain deformation used Finite element (FE) models, utilizing both elastic and hyperelastic are developed study strains probe-tissue interface, longitudinal lateral micromotion. results show that tip material exceeds commonly range. This finding suggests use a nonlinear model more realistic. Moreover, `kill zone', denoting distances within greater than 5%, estimated extend 20 μm from displacement.