Autoradiographic localization of thyrotropin-releasing hormone receptors in the rat central nervous system
作者： S Manaker , A Winokur , WH Rostene , TC Rainbow
DOI: 10.1523/JNEUROSCI.05-01-00167.1985
关键词:
摘要: We employed quantitative autoradiography to examine the distribution of thyrotropin-releasing hormone (TRH) receptors in rat CNS. The binding [3H]3-methyl-histidine-TRH [( 3H]MeTRH) TRH frozen brain sections was saturable, a high affinity (Kd = 5 nM), and specific for analogs. Autoradiograms [3H]MeTRH showed highest concentrations rhinencephalon, including accessory olfactory bulb, nuclei amygdala, ventral dentate gyrus subiculum hippocampus. Moderate receptor were found within thalamus hypothalamus, most regions rhombencephalon, such as cranial nerve nuclei, substantia gelatinosa spinal cord. Neocortex basal ganglia contained low densities receptors. This correlates well with sensitivity known effects TRH, suggests that may mediate actions
sci-hub.se 参考文章(67)
Patricia M. Hinkle, Eugene L. Woroch, Armen H. Tashjian, Receptor-binding affinities and biological activities of analogs of thyrotropin-releasing hormone in prolactin-producing pituitary cells in culture. Journal of Biological Chemistry. ,vol. 249, pp. 3085- 3090 ,(1974) , 10.1016/S0021-9258(19)42641-0
David R. Burt, Marcel A. Ajah, TRH receptors in fish. General and Comparative Endocrinology. ,vol. 53, pp. 135- 142 ,(1984) , 10.1016/0016-6480(84)90233-8
L.P. Renaud, J.B. Martin, Thyrotropin releasing hormone (TRH): depressant action on central neuronal activity. Brain Research. ,vol. 86, pp. 150- 154 ,(1975) , 10.1016/0006-8993(75)90648-4
M. J. Kubek, M. A. Rea, Z. I. Hodes, M. H. Aprison, Quantitation and Characterization of Thyrotropin-Releasing Hormone in Vagal Nuclei and Other Regions of the Medulla Oblongata of the Rat Journal of Neurochemistry. ,vol. 40, pp. 1307- 1313 ,(1983) , 10.1111/J.1471-4159.1983.TB13571.X
CHARLES OLIVER, ROBERT L. ESKAY, NIRA BEN-JONATHAN, JOHN C. PORTER, Distribution and concentration of TRH in the rat brain. Endocrinology. ,vol. 95, pp. 540- 546 ,(1974) , 10.1210/ENDO-95-2-540
T. Hökfelt, K. Fuxe, O. Johansson, S. Jeffcoate, N. White, Thyrotropin releasing hormone (TRH)-containing nerve terminals in certain brain stem nuclei and in the spinal cord Neuroscience Letters. ,vol. 1, pp. 133- 139 ,(1975) , 10.1016/0304-3940(75)90028-2
DAVID R. BURT, RICHARD L. TAYLOR, Binding sites for thyrotropin-releasing hormone in sheep nucleus accumbens resemble pituitary receptors. Endocrinology. ,vol. 106, pp. 1416- 1423 ,(1980) , 10.1210/ENDO-106-5-1416
L. P. RENAUD, J. B. MARTIN, P. BRAZEAU, Depressant action of TRH, LH-RH and somatostatin on activity of central neurones. Nature. ,vol. 255, pp. 233- 235 ,(1975) , 10.1038/255233A0
M. Palkovits, Isolated removal of hypothalamic or other brain nuclei of the rat. Brain Research. ,vol. 59, pp. 449- 450 ,(1973) , 10.1016/0006-8993(73)90290-4
Toni L. Stanton, Andrew Winokur, Alexander L. Beckman, Reversal of natural CNS depression by TRH action in the hippocampus Brain Research. ,vol. 181, pp. 470- 475 ,(1980) , 10.1016/0006-8993(80)90632-0