VapBC22 toxin-antitoxin system from Mycobacterium tuberculosis is required for pathogenesis and modulation of host immune response

作者: Sakshi Agarwal , Arun Sharma , Rania Bouzeyen , Amar Deep , Harsh Sharma

DOI: 10.1126/SCIADV.ABA6944

关键词:

摘要: Virulence-associated protein B and C toxin-antitoxin (TA) systems are widespread in prokaryotes, but their precise role in physiology is poorly understood. We have functionally …

参考文章(76)
Apoorva Bhatt, Virginie Molle, Gurdyal S. Besra, William R. Jacobs, Laurent Kremer, The Mycobacterium tuberculosis FAS-II condensing enzymes: their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug development. Molecular Microbiology. ,vol. 64, pp. 1442- 1454 ,(2007) , 10.1111/J.1365-2958.2007.05761.X
Kavita Deonarine, Monica C Panelli, Mitchell E Stashower, Ping Jin, Kina Smith, Herbert B Slade, Christopher Norwood, Ena Wang, Francesco M Marincola, David F Stroncek, Gene expression profiling of cutaneous wound healing. Journal of Translational Medicine. ,vol. 5, pp. 11- 11 ,(2007) , 10.1186/1479-5876-5-11
Jeffery S. Cox, Bing Chen, Michael McNeil, William R. Jacobs, Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature. ,vol. 402, pp. 79- 83 ,(1999) , 10.1038/47042
Stoyan Bardarov, Svetoslav Bardarov, Martin S. Pavelka, Vasan Sambandamurthy, Michelle Larsen, JoAnn Tufariello, John Chan, Graham Hatfull, William R. Jacobs, Specialized transduction: an efficient method for generating marked and unmarked targeted gene disruptions in Mycobacterium tuberculosis, M. bovis BCG and M. smegmatis. Microbiology. ,vol. 148, pp. 3007- 3017 ,(2002) , 10.1099/00221287-148-10-3007
Iris Keren, Niilo Kaldalu, Amy Spoering, Yipeng Wang, Kim Lewis, Persister cells and tolerance to antimicrobials. Fems Microbiology Letters. ,vol. 230, pp. 13- 18 ,(2004) , 10.1016/S0378-1097(03)00856-5
Shaun B. Walters, Eugenie Dubnau, Irina Kolesnikova, Francoise Laval, Mamadou Daffe, Issar Smith, The Mycobacterium tuberculosis PhoPR two‐component system regulates genes essential for virulence and complex lipid biosynthesis Molecular Microbiology. ,vol. 60, pp. 312- 330 ,(2006) , 10.1111/J.1365-2958.2006.05102.X
Yoshihiro Yamaguchi, Masayori Inouye, Regulation of growth and death in Escherichia coli by toxin–antitoxin systems Nature Reviews Microbiology. ,vol. 9, pp. 779- 790 ,(2011) , 10.1038/NRMICRO2651
Yurong Wen, Ester Behiels, Bart Devreese, Toxin-Antitoxin systems: their role in persistence, biofilm formation, and pathogenicity. Pathogens and Disease. ,vol. 70, pp. 240- 249 ,(2014) , 10.1111/2049-632X.12145
Darlynn Korns, S. Courtney Frasch, Ruby Fernandez-Boyanapalli, Peter M. Henson, Donna L. Bratton, Modulation of macrophage efferocytosis in inflammation. Frontiers in Immunology. ,vol. 2, pp. 57- 57 ,(2011) , 10.3389/FIMMU.2011.00057