A comparison of wire brush and diamond fraisesuperficial dermabrasion for photoaged skin

摘要: Background: Superficial dermabrasion has a proven beneficial effect on photoaged skin, but little is known about the differences between two major modalities used in dermabrasion, diamond fraise (DF) and wire brush (WB). Objective: We compared clinical, immunohistologic, biochemical changes after superficial with DF WB. Methods: Eight patients (mean age, 68 years; range, 49 to 80 years) underwentfacial level of papillary dermis. Clinical assessments were performed at baseline 3 12 weeks dermabrasion. Biopsy specimens taken from both dermabraded halves same time points assessed by routine histologic immunohistologic examinations, Western blot analysis, radioimmunoassay. Scoring intracellular extracellular transforming growth factor-β1 was based semiquantitative ordinal scale (0=no staining 4=maximum staining) half-unit increments. The score for each specimen represents average values obtained four high-power fields. Results: Both methods resulted significant resolution actinic keratoses, lentigines, wrinkling. No statistical significance noted regard clinical efficacy. Significantly fewer milia occurred than Solar elastosis decreased WB DF. Immunohistologic examination demonstrated highly increase dermal fibroblast amino terminal procollagen I (type pN-collagen) baseline. Staining had peak week 3, still significantly increased blotting type pN-collagen 5.4-fold ( p =0.01) 4.9-fold =0.002) Similarly, produced =0.006) 5.1-fold =0.008) III showed 6.1-fold =0.07) 3.9-fold =0.04) 3.8-fold =0.05) weeks. Transforming (3.3±0.2) (3.7±0.2) (1.2±0.2, Conclusion: WP appears be similarly efficaciousin treatment skin. Significant increases pN-collagen, TGF-β1 dermis types These results suggest that activity consequent collagen synthesis underlie improvement.