摘要: The islet contains a dense vascular structure of several features. expression endothelial growth factor (VEGF)-A in beta cells is indispensable for the formation this structure. Thus, cell-specific VEGF-A-deficient mouse (RIP-Cre:Vegf(fl/fl)) useful studying role vasculature on function islets and regulation cell mass. Studies using RIP-Cre:Vegf(fl/fl) mice revealed that defects normal are associated with abnormal insulin secretion concluded system essential into blood stream. On other hand, whereas might be involved mass model diabetes shows number correlate mass, show almost response expansion presence resistance. However, bone marrow transplantation induces control mice, it does not induce proper mice. These data indicate roles VEGF-A depends stimulus islets.
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