Formulation Design, Preparation and In vitro – In vivo Evaluation of Propranolol Hydrochloride Transdermal Patches using Hydrophilic and Hydrophobic Polymer complex

摘要: The purpose of the current study was to establish a hydrophilic lipihlilic polymer complex on basis in vitro and vivo evaluations simulated skin structure order control release propranolol hydrochloride from transdermal patches administered transdermally rabbits. Transdermal (PPN) were formulated employing ethyl cellulose with Poly vinyl pyrrolidine (PVP) hydroxyl propyl methyl (HPMC) different ratios (1:2, 1:4, 1:6, 2:1, 4:1, 6:1 w/w) as film formers for each polymer. Polyvinyl alcohol used prepare backing membrane dibutyl phthalate plasticizer. Physicochemical parameters including moisture content, weight variation, water vapor transmission, folding endurance, tensile strength, rat abdomen permeation scanning electron microscopy studied. selected formulation F6 adopted evaluation by It can be predicted that (EC:PVP at w/w ratio) has greater potency drug (56.33%) controlled fashion over period 48 hr. present demonstrated potential fabricated matrix films prolonged Hypertension therapy.