Long Circulation and Tumor Accumulation
作者： Sandra N. Ekdawi , Andrew S. Mikhail , Shawn Stapleton , Jinzi Zheng , Sina Eetezadi
DOI: 10.1007/978-1-4614-7876-8_20
关键词:
摘要: Nanoparticles have been employed in cancer management as vectors to deliver chemotherapeutic and/or imaging agents tumors. Enhanced tumor accumulation occurs by virtue of the long circulation properties nanocarrier and enhanced permeability retention effect that is characteristic solid The versatility nanoparticle platform has enabled design development various nanocarriers differing physicochemical such surface composition, size, charge, shape. While can influence pharmacokinetics biodistribution a formulation, total deposition be further impacted inherent pathophysiology tissue. This chapter presents nature impact on accumulation, particularly context microenvironment. In vivo barriers, opsonization, impaired blood flow, heterogeneous vascular interstitial impede effective delivery their cargo are discussed herein, while strategies overcome them enhance nanoparticles presented.
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