Efficacy of chitosan dressing on endoscopic sinus surgery: a systematic review and meta-analysis.

摘要: Chitosan dressing might be promising to promote the recovery following endoscopic sinus surgery (ESS). However, results remain controversial. We conducted a systematic review and meta-analysis explore influence of chitosan on ESS. PubMed, EMbase, Web science, EBSCO, Cochrane library databases were systematically searched. Randomized controlled trials (RCTs) assessing effect included. Two investigators independently searched articles, extracted data, assessed quality included studies. The primary outcomes synechia hemostasis. Meta-analysis was performed using random-effect model. Four RCTs involving 268 patients in meta-analysis. Overall ESS, compared with control intervention, significantly reduced (RR = 0.25; 95% CI 0.13–0.49; P < 0.0001) promoted hemostasis (RR = 1.70; 1.37–2.11; P < 0.00001), but showed no impact granulations (RR = 1.18; 0.72–1.95; P = 0.52), mucosal edema (RR = 0.88; 0.60–1.29; P = 0.51), crusting (RR = 0.85; 0.48–1.53; P = 0.60), infection 0.51–1.52; P = 0.64). Compared could decrease improve hemostasis, had granulations, edema, infection.