Objective Olfactory Evaluation of Self-reported Olfactory Dysfunction in a Case Series of 86 COVID-19 Patients

作者: Jerome R. Lechien , Pierre Cabaraux , Carlos M. Chiesa-Estomba , Mohamad Khalife , Stéphane Hans

DOI: 10.1101/2020.05.03.20088526

关键词:

摘要: Objective: To investigate olfactory dysfunction in patients with mild COVID-19 through patient-reported outcome questionnaires and objective psychophysical testing. Methods: Adult self-reported sudden-onset were recruited a public call for participation from the University of Mons. Demographic data, pathologic conditions, general otolaryngological symptoms collected, nasal complaints evaluated sino-nasal outcome-22 (SNOT-22). Subjective gustatory status was National Health Nutrition Examination Survey (NHNES) short version Questionnaire Olfactory Disorders-Negative Statements. Objective using an test (Identification Sniffin Stick test). Results : 86 completed study. The mean age 42 + or - 12 years. most common fatigue (75%), headache (63%), obstruction (58%), dysgeusia (51%), postnasal drip (49%), cough (49%) myalgia (46%). On NHNES, total loss taste smell reported by 51% 74% patients, respectively. 65% smell, while remainder partial loss. testing found 41 anosmic (48%), hyposmics (14%), 33 normosmics (38%) patients. There no correlation between results subjective reports drip, these absent 69% Conclusion A significant proportion reporting related to infection do not have on Furthermore, majority those measured did corresponding obstruction.

参考文章(16)
Neil Bhattacharyya, Lynn J. Kepnes, Contemporary assessment of the prevalence of smell and taste problems in adults Laryngoscope. ,vol. 125, pp. 1102- 1106 ,(2015) , 10.1002/LARY.24999
C. de Dorlodot, M. Horoi, P. Lefebvre, S. Collet, B. Bertrand, P. Eloy, A.-L. Poirrier, French adaptation and validation of the Sino-Nasal Outcome Test-22: A prospective cohort study on quality of life among 422 subjects Clinical Otolaryngology. ,vol. 40, pp. 29- 35 ,(2015) , 10.1111/COA.12315
Motohiko Suzuki, Koichi Saito, Wei-Ping Min, Costin Vladau, Kazunori Toida, Hirotaka Itoh, Shingo Murakami, Identification of Viruses in Patients With Postviral Olfactory Dysfunction Laryngoscope. ,vol. 117, pp. 272- 277 ,(2007) , 10.1097/01.MLG.0000249922.37381.1E
Jay F. Piccirillo, Michael G. Merritt, Michele L. Richards, Psychometric and clinimetric validity of the 20-Item Sino-Nasal Outcome Test (SNOT-20) Otolaryngology-Head and Neck Surgery. ,vol. 126, pp. 41- 47 ,(2002) , 10.1067/MHN.2002.121022
Jason Netland, David K. Meyerholz, Steven Moore, Martin Cassell, Stanley Perlman, Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2. Journal of Virology. ,vol. 82, pp. 7264- 7275 ,(2008) , 10.1128/JVI.00737-08
Jose L. Mattos, Campbell Edwards, Rodney J. Schlosser, Madison Hyer, Jess C. Mace, Timothy L. Smith, Zachary M. Soler, A brief version of the questionnaire of olfactory disorders in patients with chronic rhinosinusitis International Forum of Allergy & Rhinology. ,vol. 9, pp. 1144- 1150 ,(2019) , 10.1002/ALR.22392
Yan‐Chao Li, Wan‐Zhu Bai, Tsutomu Hashikawa, The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients Journal of Medical Virology. ,vol. 92, pp. 552- 555 ,(2020) , 10.1002/JMV.25728
Jerome R. Lechien, Carlos M. Chiesa-Estomba, Daniele R. De Siati, Mihaela Horoi, Serge D. Le Bon, Alexandra Rodriguez, Didier Dequanter, Serge Blecic, Fahd El Afia, Lea Distinguin, Younes Chekkoury-Idrissi, Stéphane Hans, Irene Lopez Delgado, Christian Calvo-Henriquez, Philippe Lavigne, Chiara Falanga, Maria Rosaria Barillari, Giovanni Cammaroto, Mohamad Khalife, Pierre Leich, Christel Souchay, Camelia Rossi, Fabrice Journe, Julien Hsieh, Myriam Edjlali, Robert Carlier, Laurence Ris, Andrea Lovato, Cosimo De Filippis, Frederique Coppee, Nicolas Fakhry, Tareck Ayad, Sven Saussez, Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. European Archives of Oto-rhino-laryngology. ,vol. 277, pp. 2251- 2261 ,(2020) , 10.1007/S00405-020-05965-1
C. Hopkins, P. Surda, N. Kumar, Presentation of new onset anosmia during the COVID-19 pandemic. Rhinology. ,vol. 58, pp. 295- 298 ,(2020) , 10.4193/RHIN20.116