Nutritional and metabolic mechanisms in the ovary and their role in mediating the effects of diet on folliculogenesis: a perspective.

摘要: Folliculogenesis in ruminants is a nutritionally sensitive process, and short-term increases nutrient flux can stimulate folliculogenesis sheep cattle. These effects are probably mediated directly at the follicular level to modify gonadotrophin-induced follicle growth development. The appears have number of 'nutrient sensing' mechanism that may form link between status folliculogenesis. This review examines evidence for presence pathways sense from within including insulin signalling pathway, adenosine monophosphate-activated kinase (AMPK), hexosamine peroxisome proliferator-activated receptors (PPARs) leptin. then assesses available concerning their mechanisms speculates on how these integrated into FSH adjust gonadotrophin-stimulated function. We conclude there good suggest does contain more than one functional pathway intra-follicular some FSH-mediated functions such as synthesis oestradiol, granulosa cells. include insulin, AMPK, There also case integration PPARs sensing flux. However, little present biosynthetic has significance sensor Further study will be required fully understand cross-talk with pathways.