Cytogenetics of twelve cases of uveal melanoma and patterns of nonrandom anomalies and isochromosome formation

摘要: Abstract We present cytogenetic data of 12 new cases uveal melanoma. One case showed a hypotetraploid chromosome number; the others were near-diphoid. Underrepresentation or monosomy 3 as well multiplication chromosomes 8, 8q, regions 8q was found in five cases. Both anomalies observed three In two these, resulted from isochromosome formation. The smallest multiplicated region seemed to be 8q23–24→qter. Chromosome 6 without 3. Aberrations 21 seen and only change them. These may define subgroup An anomaly 1 Anomalies other detected at most each. Nonclonal centromeric telomeric associations one different nonclonal ring another. exclusively tumors with ciliary body involvement, while pure choroideal melanomas. A review published untreated melanoma supports our finding that is frequently associated but rarely 6, whereas opposite true for disomy 3, isochromosomes are closely Thus, cells seem predispose