Further studies on the anticancer activity of citrus limonoids.

摘要: Research in this laboratory has shown that some citrus limonoids can inhibit the development of 7,12-dimethylbenz[a]anthracene-induced oral tumors. The data from these studies have suggested certain rings limonoid nucleus may be critical to antineoplastic activity. Using hamster cheek pouch model, three new (ichangensin, deoxylimonin, and obacunone) now been tested for cancer chemopreventive In first experiment, it was found treatments with ichangensin had no effect on tumor number or burden. second obacunone reduced burden by 25 40%, respectively, whereas deoxylimonin 30 50%, respectively. results were significant, p < 0.05. Overall, indicated changes A ring lead a loss anticancer activity, D tolerated without any apparent biological