Cytochrome P450-derived eicosanoids and heart function

作者: K. Lockhart Jamieson , Tomoko Endo , Ahmed M. Darwesh , Victor Samokhvalov , John M. Seubert

DOI: 10.1016/J.PHARMTHERA.2017.05.005

关键词:

摘要: The cytochrome P450 monooxygenase system (CYP) is a multigene superfamily of enzymes, which are important in the metabolism foreign and endogenous compounds. CYP isoforms metabolize number n-3 n-6 polyunsaturated fatty acids (PUFA), including linoleic acid (18:2n6, LA), arachidonic (20:4n6, AA), ecosapentaenoic (20:5n3, EPA) docosahexaenoic (22:6n3, DHA) into bioactive lipid mediators, termed eicosanoids. CYP-derived eicosanoids have numerous effects toward physiological pathophysiological events within body, depends on type, quantity timing metabolites produced. Alterations composition concentrations been shown to role cardiovascular disease (CVD). functional isozymes processes heart rapidly expanding field research. Numerous studies investigated beneficial detrimental epoxygenase derived AA, epoxyeicosatrienoic (EET) ω-hydroxylase products, hydroxyeicosatetraenoic (HETE), both cardiac vascular function disease. Emerging research revealing importance other mediators generated from isozymes, such as epoxyeicosatetraenoic (EEQ) epoxydocosapentaenoic (EDP), formed EPA DHA LA. Important determinants genetics, gender age regulating produced PUFA. Obtaining better understanding complex will provide valuable insight for basic clinical researchers investigation CVD.

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