ZEB1 expression in endometrial biopsy predicts lymph node metastases in patient with endometrial cancer.
作者： Gang Feng , Xiangming Wang , Xiaozhi Cao , Lijuan Shen , Jiansheng Zhu
DOI: 10.1155/2014/680361
关键词:
摘要: Purpose. The purpose of this study was to analyze the expression zinc-finger E-box-binding homeobox 1 (ZEB1) in endometrial biopsy and its correlation with preoperative characteristics, including lymph node metastases patient cancer. Methods. Using quantitative RT-PCR, ZEB1 expressions from 452 patients were measured. relationship between characteristics analyzed. Results. significantly associated subtype, grade, myometrial invasion, metastases. Lymph could be identified a sensitivity 57.8% at specificity 74.1% by biopsy. Based on combination expression, 62.1% 96.2% prior hysterectomy. Conclusion. help physicians better predict metastasis cancer
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Giorgio Bogani, Sean C. Dowdy, William A. Cliby, Fabio Ghezzi, Diego Rossetti, Andrea Mariani, Role of pelvic and para-aortic lymphadenectomy in endometrial cancer: Current evidence Journal of Obstetrics and Gynaecology Research. ,vol. 40, pp. 301- 311 ,(2014) , 10.1111/JOG.12344
Gab-Yong Bae, So-Jung Choi, Ji-Seon Lee, Jisuk Jo, Jinseon Lee, Jhingook Kim, Hyuk-Jin Cha, Loss of E-cadherin activates EGFR-MEK/ERK signaling, which promotes invasion via the ZEB1/MMP2 axis in non-small cell lung cancer. Oncotarget. ,vol. 4, pp. 2512- 2522 ,(2013) , 10.18632/ONCOTARGET.1463
Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): a randomised study. The Lancet. ,vol. 373, pp. 125- 136 ,(2009) , 10.1016/S0140-6736(08)61766-3
Pamela T. Soliman, Michael Frumovitz, Whitney Spannuth, Marilyn J. Greer, Sheena Sharma, Kathleen M. Schmeler, Pedro T. Ramirez, Charles F. Levenback, Lois M. Ramondetta, Lymphadenectomy during endometrial cancer staging: practice patterns among gynecologic oncologists. Gynecologic Oncology. ,vol. 119, pp. 291- 294 ,(2010) , 10.1016/J.YGYNO.2010.07.011
Motoyuki Hashiguchi, Shinichi Ueno, Masahiko Sakoda, Satoshi Iino, Kiyokazu Hiwatashi, Koji Minami, Kei Ando, Yuko Mataki, Kosei Maemura, Hiroyuki Shinchi, Sumiya Ishigami, Shoji Natsugoe, Clinical implication of ZEB-1 and E-cadherin expression in hepatocellular carcinoma (HCC). BMC Cancer. ,vol. 13, pp. 572- 572 ,(2013) , 10.1186/1471-2407-13-572
Tisheeka R. Graham, Haiyen E. Zhau, Valerie A. Odero-Marah, Adeboye O. Osunkoya, K. Sean Kimbro, Mourad Tighiouart, Tongrui Liu, Jonathan W. Simons, Ruth M. O'Regan, Insulin-like growth factor-I-dependent up-regulation of ZEB1 drives epithelial-to-mesenchymal transition in human prostate cancer cells Cancer Research. ,vol. 68, pp. 2479- 2488 ,(2008) , 10.1158/0008-5472.CAN-07-2559
Meenakshi Singh, Nicole S Spoelstra, Annie Jean, Erin Howe, Kathleen C Torkko, Hilda R Clark, Douglas S Darling, Kenneth R Shroyer, Kathryn B Horwitz, Russell R Broaddus, Jennifer K Richer, ZEB1 expression in type I vs type II endometrial cancers: a marker of aggressive disease Modern Pathology. ,vol. 21, pp. 912- 923 ,(2008) , 10.1038/MODPATHOL.2008.82
Julie A. Quinlivan, Rodney W. Petersen, James L. Nicklin, Accuracy of frozen section for the operative management of endometrial cancer British Journal of Obstetrics and Gynaecology. ,vol. 108, pp. 798- 803 ,(2001) , 10.1111/J.1471-0528.2001.00196.X
Simone Spaderna, Otto Schmalhofer, Mandy Wahlbuhl, Arno Dimmler, Katja Bauer, Aneesa Sultan, Falk Hlubek, Andreas Jung, Dennis Strand, Andreas Eger, Thomas Kirchner, Jürgen Behrens, Thomas Brabletz, The Transcriptional Repressor ZEB1 Promotes Metastasis and Loss of Cell Polarity in Cancer Cancer Research. ,vol. 68, pp. 537- 544 ,(2008) , 10.1158/0008-5472.CAN-07-5682
Simone Spaderna, Otto Schmalhofer, Falk Hlubek, Geert Berx, Andreas Eger, Susanne Merkel, Andreas Jung, Thomas Kirchner, Thomas Brabletz, A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer. Gastroenterology. ,vol. 131, pp. 830- 840 ,(2006) , 10.1053/J.GASTRO.2006.06.016