KIN-4/MAST kinase promotes PTEN-mediated longevity of Caenorhabditis elegans via binding through a PDZ domain.
作者： Seon Woo A. An , Eun‐Seok Choi , Wooseon Hwang , Heehwa G. Son , Jae‐Seong Yang
DOI: 10.1111/ACEL.12906
关键词:
摘要: PDZ domain-containing proteins (PDZ proteins) act as scaffolds for protein-protein interactions and are crucial a variety of signal transduction processes. However, the role in organismal lifespan aging remains poorly understood. Here, we demonstrate that KIN-4, microtubule-associated serine-threonine (MAST) protein kinase, is key longevity factor acting through binding PTEN phosphatase Caenorhabditis elegans. Through targeted genetic screen proteins, find kin-4 required long daf-2/insulin/IGF-1 receptor mutants. We then show neurons tissues longevity-promoting kin-4. domain KIN-4 binds PTEN, daf-2 Moreover, interaction between essential extended As many aspects regulation C. elegans evolutionarily conserved, MAST family kinases may regulate and/or age-related diseases mammals their with PTEN.
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