Histological Landmarks in Corneal Dystrophy: Pathology of Corneal Dystrophies

摘要: Corneal dystrophies are bilateral, progressive, genetically determined noninflammatory diseases restricted to the cornea. These characterized by deposition of nonnative protein or other material, both intracellular and extracellular, within corneal layers. Dystrophies classified based on anatomical location lesions as: anterior (affecting epithelium extending into superficial stroma), stromal (which involve stroma only) posterior include Descemet's membrane endothelium). Recent additions in field genetics molecular basis have led evolution a new classification which incorporates genotypic-phenotypic features. While histopathologic study is gold standard for diagnosis, various techniques help provide additional information this area. can be considered unique as association gene-protein-disease has been approached forward direction well reverse order. In chapter, we attempt highlight histological features from cumulative evidence obtained buttons, enucleated specimens, biopsies, electron microscopic studies, histochemistry immunohistochemistry.