Development of spectral and temporal response selectivity in the auditory cortex.

摘要: The mechanisms by which hearing selectivity is elaborated and refined in early development are very incompletely determined. In this study, we documented contributions of progressively maturing inhibitory influences on the refinement spectral temporal response properties primary auditory cortex. Inhibitory receptive fields (IRFs) infant rat cortical neurons were spectrally far broader had extended over longer duration than did those adults. selective IRFs was delayed relative to that excitatory an ≈2-week period corresponded critical for plasticity. Local application a GABAA receptor antagonist revealed intracortical inhibition contributes progressive field maturation frequency. Conversely, it no effect or successive-signal recovery times. importance exposure patterned acoustic inputs suggested when both IRF disrupted pups reared continuous, moderate-intensity noise. They subsequently renormalized animals returned standard housing conditions as