Paper-based 3D microfluidic device for multiple bioassays

摘要: Abstract This study investigates a new paper-based 3D microfluidic analytical device for analyzing multiple biological fluids. A wax-printed and -impregnated was operated using tip-pinch manipulation of the thumb index fingers applied chemical reaction preloaded colorimetric indicator solutions. Chemical sensing protein glucose concentrations quantitatively analyzed by changes in color intensity image taken from three readout devices including scanner (Epson Perfection V700), microscope (USB-embedded handheld digital microscope), smartphone (LG Optimus Vu). Paper-based analytic with analyzers successfully quantified 1.5–75 μM 0–900 mg/dL concentrations. combined showed performance bioassay (1.5–75 μM) (0–50 mM) clinically relevant ranges comparable to other devices. An origami-driven is useful platform great potential application point-of-care diagnostics.