The Relationship of Chemical Structure to Biochemical Activity of Daunomycin, Adriamycin and some Structural Analogues: Effects on Viral DNA Polymerases from Oncorna Viruses

摘要: Some of the major advances in chemotherapy cancer are attributed to use chemotherapeutic “cocktails” This expression means that primary compound is used combination with other therapeutically active compounds whose mode action at least partially known. The idea increase efficacy compound. can be achieved one following ways: 1) by facilitating favourable distribution drug its site action; 2) by altering pharmacodynamics so as slow down degradation and allow it exist for longer form; 3) (perhaps most important, my opinion) by promoting “multi-site” individual components cocktail. For such an ideal combination, mechanism cocktail must approach should help reduce toxicity, since a spectrum results might reduced dose levels.