Latent profile analysis in frontotemporal lobar degeneration and related disorders: clinical presentation and SPECT functional correlates
作者： Chiara Agosti , Barbara Paghera , Antonella Alberici , Monica Di Luca , Daniela Perani
关键词:
摘要: Frontotemporal Lobar Degeneration (FTLD) thus recently renamed, refers to a spectrum of heterogeneous conditions. This same heterogeneity presentation represents the major methodological limit for correct evaluation clinical designation and brain functional correlates. At present, no study has investigated clusters due specific cognitive behavioural disturbances beyond current criteria. The aim this was identify FTLD presentation, based on profile, define their SPECT correlations. Ninety-seven patients entered study. A standardised assessment were preformed, as well perfusion imaging Latent Profile Analysis clinical, neuropsychological, data performed. Voxel-basis analysis computed. Three identified named "pseudomanic behaviour" (LC1), "cognitive" (LC2), "pseudodepressed (LC3) endophenotypes. These endophenotypes showed comparable hypoperfusion in left temporal lobe, but pattern involving: medial orbitobasal frontal cortex LC1, subcortical region LC2, right dorsolateral insula LC3. findings provide evidence that functional-cluster symptom relationship can be delineated by assessment. understanding different correlates presentations will hopefully lead possibility individuating diagnostic treatment algorithms.
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Susan E. Folstein, Marshal F. Folstein, Paul R. McHugh, F. Folstein, A PRACTICAL METHOD FOR GRADING THE COGNITIVE STATE OF PATIENTS FOR THE CLINICIAN ,(2002)
Marshal F. Folstein, Susan E. Folstein, Paul R. McHugh, “Mini-mental state” Journal of Psychiatric Research. ,vol. 12, pp. 189- 198 ,(1975) , 10.1016/0022-3956(75)90026-6
Ennio De Renzi, Fabrizia Motti, Paolo Nichelli, Imitating Gestures: A Quantitative Approach to Ideomotor Apraxia JAMA Neurology. ,vol. 37, pp. 6- 10 ,(1980) , 10.1001/ARCHNEUR.1980.00500500036003
S. E. Nadeau, Alzheimer’s disease as a window to neural mechanisms of cognition Neurology. ,vol. 61, pp. 1470- 1471 ,(2003) , 10.1212/WNL.61.11.1470
D. Neary, J. S. Snowden, L. Gustafson, U. Passant, D. Stuss, S. Black, M. Freedman, A. Kertesz, P. H. Robert, M. Albert, K. Boone, B. L. Miller, J. Cummings, D. F. Benson, Frontotemporal lobar degeneration A consensus on clinical diagnostic criteria Neurology. ,vol. 51, pp. 1546- 1554 ,(1998) , 10.1212/WNL.51.6.1546
Harold L. Blackburn, Arthur L. Benton, Revised administration and scoring of the digit span test. Journal of Consulting Psychology. ,vol. 21, pp. 139- 143 ,(1957) , 10.1037/H0047235
B. L. Miller, W. W. Seeley, P. Mychack, H. J. Rosen, I. Mena, K. Boone, Neuroanatomy of the self Evidence from patients with frontotemporal dementia Neurology. ,vol. 57, pp. 817- 821 ,(2001) , 10.1212/WNL.57.5.817
David W Loring, Roy C Martin, Kimford J Meador, Gregory P Lee, Psychometric construction of the Rey-Osterrieth complex figure: Methodological considerations and interrater reliability Archives of Clinical Neuropsychology. ,vol. 5, pp. 1- 14 ,(1990) , 10.1016/0887-6177(90)90002-7
Sandra B Chapman, Frederick J Bonte, Stephanie B Chiu Wong, Jennifer N Zientz, Linda S Hynan, Thomas S Harris, April R Gorman, Celeste A Roney, Anne M Lipton, Convergence of connected language and SPECT in variants of frontotemporal lobar degeneration. Alzheimer Disease & Associated Disorders. ,vol. 19, pp. 202- 213 ,(2005) , 10.1097/01.WAD.0000189050.41064.03
Surekha Mudivarthy, M Bhaskara Rao, Model Selection and Inference Technometrics. ,vol. 42, pp. 319- 319 ,(2000) , 10.1080/00401706.2000.10486070