Outcomes of stage IV patients with colorectal cancer treated in a single institution: What is the key to the long-term survival?

摘要: OBJECTIVES The purpose of this study is to summarize our short- and long-term treatment results for stage IV colorectal cancer (CRC) clarify the factors predicting favorable survival. METHODS Between January 2008 December 2015, 149 consecutive patients with CRC underwent initial at Nagoya University Hospital. Their clinical pathological characteristics, methods used, outcomes were retrospectively analyzed. RESULTS median observation period was 23 months. All primary metastatic lesions technically resectable in 74 patients; however, remaining 75 judged as initially unresectable. R0/1 resection during course achieved (50%). For cohort a whole, 5-year overall survival (OS) rate 35%. OS group 57%, which significantly better than that non-R0/1 (6%, p < 0.001). In group, perioperative chemotherapy improved outcome (5-year OS; 62% vs. 0%, = 0.03). tumor associated higher prognosis (3-year 20.4% 0.026). Moreover, additional use molecular targeted drugs multivariate analysis, differentiated histologic type, resection, parallel remained independent outcome. CONCLUSIONS present suggested aggressive curative might improve group.