Formula to Predict Platelet Count after Partial Splenic Arterial Embolization in Patients with Hypersplenism

作者: Akihiko Osaki , Takeshi Suda , Nobuo Waguri , Toru Ishikawa , Takeshi Yokoo

DOI: 10.1016/J.JVIR.2012.03.008

关键词:

摘要: Purpose To establish a formula to guide appropriate embolization volume for postprocedural platelet gain following partial splenic arterial (PSE) hypersplenism. Materials and Methods The hepatic (Vh) (Vsp) were measured by using 2-mm-thick computed tomography images before after PSE in 20 patients with various chronic liver diseases. A was derived from the relationship between count increase ratio (dPlt%) organ volumes, which then evaluated another cohort. Results After an of median 72.1% spleen (interquartile range, 38.2%–93.8%), dPlt% 67.7% ± 40.0 significantly correlated increasing Vh Vsp ( P = .019, ρ 0.52). Because difference Vh/Vsp (eVsp%; .0003, 0.72), estimated could be eVsp%. actual 0.72). When cohort 14 cases, strict correlation observed Conclusions These data suggest that can predicted procedure anticipated volume. use such prediction prevent too much or little embolization, thereby leading improvement risk/return trade-off PSE.

参考文章(33)
Nobuhiko Taniai, Yasuhiro Mamada, Masahiko Onda, Takashi Tajiri, Tatsuo Kumazaki, Hiroshi Yoshida, Long-term hematological and biochemical effects of partial splenic embolization in hepatic cirrhosis. Hepato-gastroenterology. ,vol. 49, pp. 1445- 1448 ,(2002)
PJ Fielder, AL Gurney, E Stefanich, M Marian, MW Moore, K Carver-Moore, FJ de Sauvage, Regulation of Thrombopoietin Levels by c-mpl-Mediated Binding to Platelets Blood. ,vol. 87, pp. 2154- 2161 ,(1996) , 10.1182/BLOOD.V87.6.2154.BLOODJOURNAL8762154
Horng-Yuan Wang, Tsang-En Wang, Fung J Lin, Wen-Shiung Chang, Fei-Shih Yang, Shou-Chuan Shih, Shee-Chan Lin, Partial splenic embolization: 12-month hematological effects and complications. Hepato-gastroenterology. ,vol. 55, pp. 1838- 1842 ,(2008)
Motonobu Watanabe, Soichiro Murata, Ikuka Hashimoto, Yoritaka Nakano, Osamu Ikeda, Yasuyuki Aoyagi, Ryota Matsuo, Kiyoshi Fukunaga, Hiroshi Yasue, Nobuhiro Ohkohchi, Platelets contribute to the reduction of liver fibrosis in mice Journal of Gastroenterology and Hepatology. ,vol. 24, pp. 78- 89 ,(2009) , 10.1111/J.1440-1746.2008.05497.X
Robert McMillan, Lei Wang, Aaron Tomer, Janet Nichol, Jeanne Pistillo, Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP Blood. ,vol. 103, pp. 1364- 1369 ,(2004) , 10.1182/BLOOD-2003-08-2672
E.G. Giannini, F. Botta, P. Borro, P. Dulbecco, E. Testa, C. Mansi, V. Savarino, R. Testa, Application of the platelet count/spleen diameter ratio to rule out the presence of oesophageal varices in patients with cirrhosis: A validation study based on follow-up Digestive and Liver Disease. ,vol. 37, pp. 779- 785 ,(2005) , 10.1016/J.DLD.2005.05.007
Hideya Noguchi, Kenji Hirai, Yoshinori Aoki, Kenji Sakata, Kyuichi Tanikawa, Changes in platelet kinetics after a partial splenic arterial embolization in cirrhotic patients with hypersplenism Hepatology. ,vol. 22, pp. 1682- 1688 ,(1995) , 10.1002/HEP.1840220611
Atsushi Nanashima, Hiroyuki Yamaguchi, Shinichi Shibasaki, Shigeyuki Morino, Noboru Ide, Hiroaki Takeshita, Takashi Tsuji, Terumitsu Sawai, Tohru Nakagoe, Takeshi Nagayasu, Youji Ogawa, Relationship between CT volumetry and functional liver volume using technetium-99m galactosyl serum albumin scintigraphy in patients undergoing preoperative portal vein embolization before major hepatectomy: a preliminary study. Digestive Diseases and Sciences. ,vol. 51, pp. 1190- 1195 ,(2006) , 10.1007/S10620-006-8031-X