Photoperiod, reproduction, and immunity in select strains of inbred mice.

摘要: The purpose of this study was to determine whether decreased day lengths affect reproduction or the immune system in inbred mice. Irrespective a nocturnal pineal melatonin rise, signal for length information, body and testis weights were same various strains 8 weeks after transfer from long short days (16 h light/day) compared mice that remained days. Serum testosterone unaffected by photoperiod shift. second goal shift influenced lymphocyte populations spleen blood, as well innate cell-mediated cell functions C3H/HeN mice, an strain with robust rhythm. By flow cytometry, stable percentage number B cells, T natural killer cells identified both during night. This complement immunophenotypes suggests equivalent functional capabilities persist secondary lymphoid tissue irrespective length. supported findings cytolytic activity splenic (innate immunity) antigen-induced cell-dependent antibody production (adaptive similar In numbers but not helper subset percentages (i.e., naive, memory, cytotoxic, activated) augmented days, consequence increased circulating cells. Day differences certain circulation may forecast photoperiod-mediated alterations responsiveness pathogens are associated change season. At night, reduced proportion cytotoxic (long days), increases activated (short NK days) relative daytime, surveillance function select adapt circadian transitions even highly species. Thus, retain influence trait-specific aspects reproductive function.