Who watches the watchmen? Regulation of the expression and activity of sirtuins.
作者： Marcin Buler , Ulf Andersson , Jukka Hakkola
关键词:
摘要: Sirtuins (SIRT1-7) are a family of nicotine adenine dinucleotide (NAD+)-dependent enzymes that catalyze post-translational modifications proteins. Together, they regulate crucial cellular functions and traditionally associated with aging longevity. Dysregulation sirtuins plays an important role in major diseases, including cancer metabolic, cardiac, neurodegerative diseases. They extensively regulated response to wide range stimuli, nutritional metabolic challenges, inflammatory signals or hypoxic oxidative stress. Each sirtuin is individually tissue- cell-specific manner. The control expression involves all the points regulation, transcriptional mechanisms microRNAs. Collectively, these protein levels, localization, enzymatic activity sirtuins. In many cases, regulators also their substrates, which lead formation intricate regulatory networks extensive feedback loops. this review, we highlight mediating physiologic pathologic regulation activity. We discuss consequences on function physiology.-Buler, M., Andersson, U., Hakkola, J. Who watches watchmen? Regulation
fasebj.org 参考文章(229)
Ping Liu, Michael J. Wilson, miR-520c and miR-373 upregulate MMP9 expression by targeting mTOR and SIRT1, and activate the Ras/Raf/MEK/Erk signaling pathway and NF-κB factor in human fibrosarcoma cells. Journal of Cellular Physiology. ,vol. 227, pp. 867- 876 ,(2012) , 10.1002/JCP.22993
Wenxiu Yang, Yan Zou, Man Zhang, Nan Zhao, Qi Tian, Min Gu, Wei Liu, Rui Shi, Yang Lü, Weihua Yu, Mitochondrial Sirt3 Expression is Decreased in APP/PS1 Double Transgenic Mouse Model of Alzheimer’s Disease Neurochemical Research. ,vol. 40, pp. 1576- 1582 ,(2015) , 10.1007/S11064-015-1630-1
Juan Xu, Li Li, Hui-fang Yun, Ye-shan Han, MiR-138 promotes smooth muscle cells proliferation and migration in db/db mice through down-regulation of SIRT1. Biochemical and Biophysical Research Communications. ,vol. 463, pp. 1159- 1164 ,(2015) , 10.1016/J.BBRC.2015.06.076
Yuling Wang, Peng Xue, Yan Liu, Yue Cao, Xinli Jiang, Huijie Ma, SIRT1 and insulin resistance. Journal of Diabetes and Its Complications. ,vol. 30, pp. 178- 183 ,(2016) , 10.1016/J.JDIACOMP.2015.08.022
Yong-Ru Chen, Shi-Rong Fang, Yu-Cai Fu, Xiao-Hui Zhou, Ming-Yan Xu, Wen-Can Xu, Calorie restriction on insulin resistance and expression of SIRT1 and SIRT4 in rats. Biochemistry and Cell Biology. ,vol. 88, pp. 715- 722 ,(2010) , 10.1139/O10-010
YING SHI, JIANJUN HUANG, JUN ZHOU, YING LIU, XIAODAN FU, YIMIN LI, GANG YIN, JIFANG WEN, MicroRNA-204 inhibits proliferation, migration, invasion and epithelial-mesenchymal transition in osteosarcoma cells via targeting Sirtuin 1 Oncology Reports. ,vol. 34, pp. 399- 406 ,(2015) , 10.3892/OR.2015.3986
Nobuko Matsushita, Ryo Yonashiro, Yoshinobu Ogata, Ayumu Sugiura, Shun Nagashima, Toshifumi Fukuda, Ryoko Inatome, Shigeru Yanagi, Distinct regulation of mitochondrial localization and stability of two human Sirt5 isoforms Genes to Cells. ,vol. 16, pp. 190- 202 ,(2011) , 10.1111/J.1365-2443.2010.01475.X
Nady Braidy, Anne Poljak, Ross Grant, Tharusha Jayasena, Hussein Mansour, Tailoi Chan-Ling, George Smythe, Perminder Sachdev, Gilles J. Guillemin, Differential Expression of Sirtuins in the Aging rat Brain Frontiers in Cellular Neuroscience. ,vol. 9, pp. 167- 167 ,(2015) , 10.3389/FNCEL.2015.00167
Ben Zhou, Yi Zhang, Fang Zhang, Yulei Xia, Jun Liu, Rui Huang, Yuangao Wang, Yanan Hu, Jingxia Wu, Changgui Dai, Hui Wang, Yanyang Tu, Xiaozhong Peng, Yiqian Wang, Qiwei Zhai, CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1 Hepatology. ,vol. 59, pp. 2196- 2206 ,(2014) , 10.1002/HEP.26992
F. Kyle Satterstrom, William R. Swindell, Gaëlle Laurent, Sejal Vyas, Martha L. Bulyk, Marcia C. Haigis, Nuclear respiratory factor 2 induces SIRT3 expression Aging Cell. ,vol. 14, pp. 818- 825 ,(2015) , 10.1111/ACEL.12360