Immune Surveillance and Tumor Evasion

摘要: Tumors are composed of heterogeneous cell types, both diverse transformed cells the tissue origin and a variety stromal cells. The tumor themselves differ in degree aneuploidy, number identity mutations, extent genomic instability, expression surface antigens, capacity to express cytokines, growth factors, proteases, angiogenic factors. include fibroblasts, an assortment leukocytes lymphocytes, often types that make up blood vessels. Ongoing reciprocal interactions between affect establishment, progression, maintenance cancer, with immune particular mediating antitumor surveillance (Fig. 10.1). This chapter explores details surveillance, discusses mechanisms by which tumors evade this impact alcohol on both.