The comparison of equine articular cartilage progenitor cells and bone marrow-derived stromal cells as potential cell sources for cartilage repair in the horse.
作者： Helen E. McCarthy , Jennifer J. Bara , Karen Brakspear , Sim K. Singhrao , Charles W. Archer
DOI: 10.1016/J.TVJL.2011.08.036
关键词:
摘要: A chondrocyte progenitor population isolated from the surface zone of articular cartilage presents a promising cell source for cell-based repair. In this study, equine cells (ACPCs) and bone marrow-derived stromal (BMSCs) were compared as potential sources Clonally derived BMSCs ACPCs demonstrated expression fate selector gene, Notch-1, putative stem markers STRO-1, CD90 CD166. Chondrogenic induction revealed positive labelling collagen type II aggrecan. Collagen X was not detected in ACPC pellets but observed all BMSC pellets. addition, it that labelled Runx2 matrilin-1 antibodies, whereas significantly less or absent. For both types, osteogenic von Kossa staining addition to osteocalcin. Adipogenic result via oil red O types. have functional equivalence their multipotent differentiation capacity. resulted hypertrophic (endochondral) phenotype, which can limit repair tissue undergo mineralisation. may therefore be considered superior producing capable
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