作者: W.A. Daniel , H. Norman B. Wettenhall , Christine Cahill , Alex F. Roche
DOI: 10.1016/S0022-3476(75)80162-4
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摘要: In the past 15 years 450 girls have been seen because of concern about tall stature; 168 them treated with stilbestrol to control growth rate. Of latter group 87 followed after treatment for a sufficiently long time be sure had ceased and provide data this report. At onset following (mean values) were recorded: chronologic age, 13.0 years; skeletal 13.2 height, 172.9 cm; estimated mature height 180.2 potential, 7.3 cm. end interest were: reduction in final 3.5 duration therapy, 2.1 amount given, 2.3 gm; age last visit, 17.6 years. Side effects minimal, though two developed parovarian cysts that required surgery during treatment. Not included series 87, one additional girl was serous cystadenoma ovary, superficial venous thrombosis lalf. Long-term follow-up has revealed no late complications. It is concluded estrogen can reduce significantly rate almost all girls, but must carried out under very careful supervision, bearing mind possible side effects.