The Met tyrosine kinase receptor as a therapeutic target and a potential cancer stem cell factor responsible for therapy resistance (Review)
作者： Katarzyna Miekus
DOI: 10.3892/OR.2016.5297
关键词:
摘要: Abstract The MET tyrosine kinase receptor plays an important role during tumor development and progression being responsible for proliferation, morphogenetic transformation, cell motility invasiveness. High expression of the has been shown to correlate with increased growth metastasis, poor prognosis resistance radiotherapy. Moreover, activation be associated therapy resistance. occurrence targeted might related presence cancer stem cells (CSCs). CSCs are a subpopulation in that possess ability self-renewal, clonogenicity, radioresistance self-sustained protection from apoptosis. Recently, postulated as essential factor supporting functional phenotype some tumors CSC is believed This review presents results recent studies identifying potential marker initiating cells, demonstrating pivotal indicating acquiring antitumor therapy.
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