Unilateral pallidotomy in Parkinson's disease: a randomised, single-blind, multicentre trial.

摘要: Summary Background The results of several cohort studies suggest that patients with advanced Parkinson's disease would benefit from unilateral pallidotomy. We have assessed the efficacy pallidotomy in a randomised, single-blind, multicentre trial. Methods enrolled 37 who had, despite optimum pharmacological treatment, at least one following symptoms: severe response fluctuations, dyskinesias, painful dystonias, or bradykinesia. Patients were randomly assigned to within 1 month after primary outcome assessment (6 months later). was difference between groups median changes on motor examination section unified rating scale (UPDRS 3) score done off phase. Secondary measures included levodopa-induced dyskinesias (dyskinesia [DRS]) and extent disability 2). Findings UPDRS 3 improved 47 32·5, whereas control slightly worsened 52·5 56·5 (p Interpretation Unilateral is an effective treatment disease, unsatisfactory treatment.