The Cdc48 machine in endoplasmic reticulum associated protein degradation

摘要: Abstract The AAA-type ATPase Cdc48 (named p97/VCP in mammals) is a molecular machine all eukaryotic cells that transforms ATP hydrolysis into mechanic power to unfold and pull proteins against physical forces, which make up protein's structure hold it place. From the many cellular processes, involved in, its function endoplasmic reticulum associated protein degradation (ERAD) understood best. This quality control process for of secretory pathway scans folding discovers misfolded (ER), organelle, destined these their further delivery site action. Misfolded lumenal membrane ER are detected by chaperones lectins retro-translocated out degradation. Here machinery, recruited membrane, takes over. After polyubiquitylation substrate, together with dimeric co-factor complex Ufd1–Npl4 pulls away from delivers down-stream components cytosolic proteinase machine, proteasome. known details Cdc48–Ufd1–Npl4 motor triggered subject this review article. article part Special Issue entitled: AAA ATPases: Structure function.